Enzymes de Trametes versicolor impliquées dans le métabolisme de xénobiotiques

Source : JGI ("Joint Genome Institute") - MycoCosm ("The fungal genomics resource")

 

Voir un cours sur la bioremédiation par Trametes versicolor - champignon de la pourriture blanche.

Composé dégradé Nombre d'enzyme Enzyme E.C.
1,1,1-Trichloro-2,2-bis(4-chlorophenyl)éthane (DDT) 6 isoflavone reductase 1.3.1
1,2-Dichloroéthane 6 aldehyde dehydrogenase (NAD+) 1.2.1.3
1,4-Dichlorobenzene 2 6-chlorohydroxyquinol-1,2-dioxygenase 1.13.11.37
32 monooxygenase 1.14
2 monooxygenase acting on paired donors, with incorporation or reduction of molecular oxygen with NADH or NADPH as one donor 1.14.13
1 carboxymethylenebutenolidase 3.1.1.45
10 hydrolase acting on carbon-nitrogen bonds, other than peptide bonds in linear amides 3.5.1

1-Méthylnaphthalene

2-Méthylnaphthalene

 14 oxidoreductase acting on the CH-OH group of donors 1.1
22 alcohol dehydrogenase 1.1.1.1
1 oxygenase 1.13
2 monooxygenase with NADH or NADPH as one donor 1.14.13
15 salicylate 1-monooxygenase 1.14.13.1
2 oxidoreductase acting on the CH-CH group of donors 1.3.99
10 acyltransferase transferring groups other than amino-acyl groups 2.3.1
2,4-Dichlorobenzoate 27 hydrolase acting on ester bonds 3.1.1
Acide 3-chloroacrylique 22 alcohol dehydrogenase 1.1.1.1
6 aldehyde dehydrogenase (NAD+) 1.2.1.3
Atrazine 1 urease 3.5.1.5
1 hydrolase acting on carbon-nitrogen bonds, other than peptide bonds, in cyclic amidines 3.5.4
1 cyanamide hydratase 4.2.1.69
Dégradation du benzoate via la ligation au CoA 14 oxidoreductase acting on the CH-OH group of donors 1.1
24 oxidoreductase acting on the CH-OH group of donors with NAD+ or NADP+ as acceptor 1.1.1
1 3-hydroxybutyryl-CoA dehydrogenase 1.1.1.157
1 3-hydroxyacyl-CoA dehydrogenase 1.1.1.35
2 monooxygenase with NADH or NADPH as one donor 1.14.13
2 oxidoreductase acting on the CH-CH group of donors 1.3.99
2 succinate dehydrogenase 1.3.99.1
1 glutaryl-CoA dehydrogenase 1.3.99.7
10 oxygenase 2.3.1
1 acetyl-CoA C-acetyltransferase 2.3.1.9
2 hydrolase acting on ester bonds 3.1.2
4 amidase 3.5.1.4
1 nitrilase 3.5.5.1
1 acylphosphatase 3.6.1.7
6 enoyl-CoA hydratase 4.2.1.17
Dégradation du benzoate via une hydroxylation 2 hydroxyquinol 1,2-dioxygenase 1.13.11.37
2 benzaldehyde dehydrogenase (NAD+) 1.2.1.28
4 acetyl-CoA C-acyltransferase 2.3.1.16
1 5-carboxymethyl-2-hydroxymuconate δ-isomerase 5.3.3.10
Bisphenol A 14 oxidoreductase acting on the CH-OH group of donors 1.1
24 oxidoreductase acting on the CH-OH group of donors with NAD+ or NADP+ as acceptor 1.1.1
1 oxygenase 1.13
2 monooxygenase with NADH or NADPH as one donor 1.14.13
Caprolactam 7 alcohol dehydrogenase (NADP+) 1.1.1.2
1 3-hydroxyacyl-CoA dehydrogenase 1.1.1.35
2 cyclohexanone monooxygenase 1.14.13.22
2 monooxygenase with NADH or NADPH as one donor 1.3.99
5 salicylate 1-monooxygenase 2.6.1
1 gluconolactonase 3.1.1.17
10 acyltransferase transferring groups other than amino-acyl groups 3.5.1
6 enoyl-CoA hydratase 4.2.1.17
Métabolisme de médicaments - cytochrome P450 22 alcohol dehydrogenase 1.1.1.1
8 flavin-containing monooxygenase 1.14.13.8
90 unspecific monooxygenase 1.14.14.1
3 aldehyde dehydrogenase (NAD(P)+) 1.2.1.5
19 glutathione transferase 2.5.1.18
Métabolisme de médicaments - autres enzymes 2 IMP dehydrogenase 1.1.1.205
90 unspecific monooxygenase 1.14.14.1
1 orotate phosphoribosyltransferase 2.4.2.10
1 uridine phosphorylase 2.4.2.3
2 uridine kinase 2.7.1.48
1 phosphotransferase transferring phosphorus-containing groups with a phosphate group as acceptor 2.7.4
19 carboxylesterase 3.1.1.1
1 cytidine deaminase 3.5.4.5
1 nucleoside-triphosphate diphosphatase 3.6.1.19
1 GMP synthase (glutamine-hydrolysing) 6.3.5.2
Ethylbenzene 14 oxidoreductase acting on the CH-OH group of donors 1.1
10 acyltransferase transferring groups other than amino-acyl groups 2.3.1
4 acetyl-CoA C-acyltransferase 2.3.1.16
Fluorene 15 salicylate 1-monooxygenase 1.14.13.1
6 isoflavone reductase 1.3.1
Fluorobenzoate 6 isoflavone reductase 1.3.1
1 carboxymethylenebutenolidase 3.1.1.45
γ-Hexachlorocyclohexane 14 oxidoreductase acting on the CH-OH group of donors 1.1
32 monooxygenase 1.14
2 monooxygenase with NADH or NADPH as one donor 1.14.13
14 phenol 2-monooxygenase 1.14.13.7
90 unspecific monooxygenase 1.14.14.1
6 isoflavone reductase 1.3.1
1 carboxymethylenebutenolidase 3.1.1.45
11 acid phosphatase 3.1.3.2
1 4-nitrophenylphosphatase 3.1.3.41
Géraniol 1 geraniol dehydrogenase 1.1.1.183
2 oxidoreductase acting on the CH-CH group of donors 1.3.99
4 acetyl-CoA C-acyltransferase 2.3.1.16
6 enoyl-CoA hydratase 4.2.1.17
Métabolisme des xénobiotiques par le cytochrome P450 22 alcohol dehydrogenase 1.1.1.1
90 unspecific monooxygenase 1.14.14.1
3 aldehyde dehydrogenase (NAD(P)+) 1.2.1.5
1 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase 1.3.1.20
19 glutathione transferase 2.5.1.18
11 microsomal epoxide hydrolase 3.3.2.9
Naphthalene & anthracene 14 oxidoreductase acting on the CH-OH group of donors 1.1
32 monooxygenase 1.14
2 monooxygenase with NADH or NADPH as one donor 1.14.13
15 salicylate 1-monooxygenase 1.14.13.1
14 phenol 2-monooxygenase 1.14.13.7
10 methyltransferase transferring one-carbon groups 2.1.1
1 carbon-carbon lyase - aldehyde lyase 4.1.2
Styrene 2 homogentisate 1,2-dioxygenase 1.13.11.5
2 monooxygenase with NADH or NADPH as one donor 1.14.13
4 amidase 3.5.1.4
1 nitrilase 3.5.5.1
2 maleylacetoacetate isomerase 5.2.1.2
Tetrachloroethene 24 oxidoreductase acting on the CH-OH group of donors with NAD+ or NADP+ as acceptor 1.1.1
15 soluble epoxide hydrolase 3.3.2.10
Toluene and xylene 2 monooxygenase with NADH or NADPH as one donor 1.14.13
14 phenol 2-monooxygenase 1.14.13.7
2 benzaldehyde dehydrogenase (NAD+) 1.2.1.28
Trinitrotoluene 40 oxidoreductases 1

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Analgésiques / anti-inflammatoires
Ibuprofène Acétaminophène ou paracétamol
Diclofénac Naproxène
Tramadol Ketoprofène
Aspirine Phénylbutazone
Antibiotiques
Sulfamethoxazole Trimethoprime
Danofloxacine Norfloxacine
Ofloxacine Ciprofloxacine
Roxithromycine Erythromycine
Flumequine Metronidazole
Insecticide - pesticide
DDT (insecticide) Atrazine (pesticide)
Antifongique
Triclosan Epoxiconazole
Béta-bloquant
Atenolol Metoprolol
Propranolol Nebivolol
Antihypertenseur
Ibersartan Furosemide
Perturbateurs endocriniens
Bisphenol A Nonylphénol
Composés organiques aromatiques
Hydroquinone Anthraquinone
Phénol (hydroxybenzene) Anthracène
Phenanthrène p-Hydroxybenzoate
Fluorobenzene 1,4-Dichlorobenzene
Octocrylene (cosmétique) Galaxolide (fragrance)
Psychotropes
Diazepam (anxiolytique) Gemfibrozil (ou bolutol)
Carbamazépine (anti-convulsif) Gabapentine (anticonvulsif)
Fenofibrate Citalopram
Divers
2,4-Dichlorobenzoate Caprolactame
17 β-Estradiol 17 α-Ethinyl Estradiol
Lignine (organosolv - C81H92O28)

Source des fichiers SDF : "PubChem"


blanc : hydrogène - gris : carbone
bleu : azote - rouge : oxygène - jaune : soufre - vert foncé : chlore - vert clair : fluor

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